Leaders in Research

You may view the list of scholars arranged

alphabetically by class year

by institution by geography

by research topic

Norman E. Sharpless, MD Associate Professor of Medicine and Genetics Lineberger Comprehensive Cancer Center University of North Carolina School of Medicine I am a hematologist / oncologist who became interested in aging through the study of tumor suppressor genes in mice. I went to medical school at the University of North Carolina, and then received clinical training in internal medicine, hematology and oncology at the Massachusetts General Hospital and Dana-Farber Cancer Institute in Boston. I joined the clinical faculty at Harvard Medical School in July 2000, working predominantly on gastrointestinal cancers. After completing my clinical fellowship, I also received further basic science post-doctoral training in the laboratory of Dr. Ronald DePinho at the Dana-Farber. In that lab, I generated two strains of knockout mice lacking either of two related, important tumor suppressor genes: p16INK4a and p19ARF. I fully characterized the tumor susceptibility of those strains during the remainder of my post-doctoral fellowship at Harvard. I began my own lab at the University of North Carolina in the Fall of 2002, and have continued to study the function of p16INK4a and p19ARF in vivo. Currently, I am a member of the Lineberger Cancer Center, and an assistant professor of medicine and genetics in the UNC School of Medicine.

Primary Research (for Beeson Program): The Role of the Tumor Suppressor P16INK4A in Mammalian Aging.