Leaders in Research
You may view the list of scholars arranged
| Frank S. Lee, MD, PhD. Associate Professor Department of Pathology & Lab Medicine University of Pennsylvania School of Medicine
In 1998, Dr. Lee assumed his present position at the University of Pennsylvania School of Medicine, where he also serves as an attending physician on the medical pathology service. His research interests center on molecular mechanisms of activation of the stress-induced transcription factors NF-…B and HIF-1. During this time, he was exposed to Center for Neurodegenerative Disease Research at the University of Pennsylvania, and he soon after developed an interest applying his expertise in protein kinases to studying Alzheimer's disease. Dr. Lee obtained a pilot project grant from the Alzheimer's Disease Center Core to initiate studies on stress-induced protein kinases and Alzheimer's disease. These studies will be continued and expanded upon under the Beeson Scholarship. | |
| Primary Research (for Beeson Program): Nf-kB And Alzheimer's Disease
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Dr. Lee is an Assistant Professor in the Department of Pathology and Laboratory Medicine at the University of Pennsylvania School of Medicine. Dr. Lee received his B.A. from Harvard College, and then went onto to obtain M.D. and Ph.D. degrees from Harvard Medical School. From 1991 to 1994, he completed a residency in Anatomic Pathology at Brigham and Women's Hospital, Boston. Supported by a Howard Hughes Medical Institute Postdoctoral Research Fellowship for Physicians, Dr. Lee then went on to conduct research in the laboratory of Dr. Tom Maniatis at Harvard University. This research focused molecular mechanisms of activation of the transcription factor NF- …B, a protein critical to immune and inflammatory reactions. Significantly, he was the first to demonstrate that NF-…B is activated by a protein kinase cascade consisting of a mitogen-activated protein kinase and an I…B kinase, a general model which has been confirmed and extended by many other laboratories.